Using the same cables the same PCI Express slot (even tried a different slot to see if that one somehow went faulty). I determined it's not a power issue because my old card requires more juice and has a light to indicate if it is getting enough power, all systems were a go. I purchased the card on newegg.com, I'm hopefully going to my buddies tomorrow to brew some beer and will try swapping it on his machine to make sure it's not DoA. Here is my system; Motherboard: Gigabye GA-990FXA-UD3 - http://www.tigerdirect.com/applications/SearchTools/item-details.asp?EdpNo=667675 CPU: AMD FX-8150 3.6ghz (which apparently I bought the warranty for? woohoo!) http://www.newegg.com/Product/Product.aspx?Item=N82E16819103960 CPU fan: http://www.newegg.com/Product/Product.aspx?Item=N82E16835214024 Memory: http://www.tigerdirect.com/applications/SearchTools/item-details.asp?EdpNo=6688692 Graphics: HIS IceQ Radeon 7850 http://www.newegg.com/Product/Product.aspx?Item=N82E16814161405 - Old card was a GeForce GTX280 PSU: Coolermaster 750W Monitor: Samsung Syncmaster T220